Yesterday, a patient came to the outpatient clinic, recently feeling systemic fatigue, decreased appetite, aversion to greasy foods, and right upper quadrant abdominal pain. Hospital examination results showed 'positive small three yang.' Upon hearing it was the small three yang, the patient said, "Doctor, prescribe me some medication, it's just the small three yang, nothing serious." I quickly responded, "You must take this seriously. Although the small three yang has lower infectivity, the virus resides within the cell nucleus, making it more likely to progress to liver cirrhosis or even liver cancer!"

Many people still believe that the "big three yang" is severe while the "small three yang" is not a problem, which is actually a misconception. Now, let's discuss the differences between the big three yang and the small three yang.

Major and minor three positive markers are determined through the hepatitis B five-panel test. "Major three positive" refers to positivity in items 1, 3, and 5 of the hepatitis B five-panel (hepatitis B surface antigen, hepatitis B e antigen, and hepatitis B core antibody). These three positive indicators typically suggest active viral replication within the body and strong infectivity. "Minor three positive" refers to positivity in items 1, 4, and 5 of the hepatitis B five-panel (hepatitis B surface antigen, hepatitis B e antibody, and hepatitis B core antibody), with relatively weaker infectivity. Therefore, many people believe that major three positive is severe while minor three positive is harmless. This notion is incorrect. Whether it is major three positive or minor three positive, both indicate hepatitis B virus infection; the only difference is that major three positive has stronger transmission capability.

The harms associated with minor three positive in hepatitis B have increasingly gained attention among healthcare professionals specializing in liver diseases. So, what exactly are the hazards of minor three positive? And how should we take them seriously?

Hepatitis B minor three positive is a type of chronic hepatitis B. As a pathological state of hepatitis B, minor three positive can cause significant damage and harm not only to the liver but also to overall health. Even if hepatitis B minor three positive persists for a long time, it does not rule out the possibility of disease progression and exacerbation. If the condition is neglected and continues to worsen, it may lead to liver fibrosis, cirrhosis, or even hepatocellular carcinoma, severely impacting the patient's life, health, and quality of life.

The risk to others should not be underestimated. Hepatitis B is an infectious disease, and patients with minor three positive are also sources of infection, capable of transmitting the virus to healthy individuals and thereby posing a threat to others.

Any patient with Hepatitis B small three yang should undergo regular check-ups and actively receive appropriate treatment based on their actual condition. Only in this way can the harm of Hepatitis B small three yang be minimized and kept within controllable limits.

Patients with large or small three yang should pay attention to rest in daily life, avoid overwork, staying up late, and alcohol consumption. At the same time, they should regularly undergo tests for the five hepatitis B markers, liver function, hepatitis B virus testing, and liver color ultrasound. Once abnormalities are detected, timely treatment should be administered, including antiviral therapy when necessary.